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Non-invasive ultrasonic flow sensor for liquid chromatography/HPLC

Non-invasive ultrasonic flow sensor for liquid chromatography/HPLC

10 June 2024

Liquid Chromatography/HPLC is an instrument used to separate, detect, and analyze compounds. It does this by splitting a mixture into parts. Then, it does a quantitative and qualitative analysis of each part.

Scientists and researchers use chromatographs in fields like chemistry, bio-downstream process development, and pharmacy. They use them to learn about the composition, structure, and properties of samples.

In single-use pharmaceutical processes, liquid chromatographs play a crucial role in drug component analysis, quality control, research and development, metabolic studies, etc., making drug research and production more precise, efficient, and reliable.

Accurate flow rate measurement is crucial, it shows how well liquid chromatographs perform.

Traditional measurement methods present multi challenges to the accuracy of the results.

1.Flow rate fluctuations
Fluid flow rates in chromatographic instruments may fluctuate. This leads to instability and inaccuracy in flow rate measurements.

2.Changes in liquid properties
During chromatography, the fluid's properties can change. This happens due to shifts in temperature, pressure, or composition. These changes affect the accuracy of flow rate measurements.

3.Liquid viscosity
Some fluids being measured may have high viscosity, which can affect the fluid's flow performance in the chromatograph, leading to difficulties in flow rate measurements.

4.Foam and bubbles
Bubbles or foam may be present in the chromatograph, which can interfere with flow rate measurements and lead to inaccurate results.

5.Liquid contamination
Maintaining the purity and sterility of the liquid is crucial in chromatographic analysis. During flow rate measurements, it is essential to ensure that all connecting components and pipelines are sterile to prevent any bacteria or contaminants from entering the sample.

XY-TEK CG Series Clamp-On Ultrasonic Flow Sensor can address these challenges and add advantages to liquid chromatography/HPLC.

1.Clamp-on design,easy to use
It can be organically combined with pumps, pipelines, valves, and related sensors required by the chromatograph on a single frame, with optional fixed or mobile installation.

2.Non-invasive measurement, meeting high hygiene requirements
There is no need to contact the measured fluid, reducing the risk of cross-infection or contamination to a minimum and meeting the requirements for liquid purity and sterility in biopharmaceutical processes.

3.Flexible configuration
Provides 12 different pipe diameter ranges. Customization is available based on customer laboratory and industrial needs, providing a good experience whether used independently or connected upstream and downstream.

4.Wide flow rate range
Can measure flow rates as low as 25 mL/min or as high as 100,000 mL/min.

5.High precision
Measurement error as low as ±3%.

6.Standard output mode
Can seamlessly integrate with customer chromatographic analysis systems.

7.Independent R&D by XY-TEK
Products are in stock, we can provide faster delivery to end customers, also in-time good technical support and after-sales service.

Please feel free to contact us to discuss how the XY-TEK CG series ultrasonic flow sensor can serve your product and contribute to your success.

We would be delighted to arrange a product demonstration or provide further information to help you make an informed decision. Global@xy-tek.cn

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